Michael Symon Pork Tenderloin Sandwich Recipe

Updated November 5, 2026

Total time
40 min
prep 25 min · cook 15 min
Serves
4
portions as written

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Michael Symon Pork Tenderloin Sandwich Recipe

This pork tenderloin sandwich is a Cleveland-style classic, made famous by chef Michael Symon. Thin slices of pork tenderloin are pounded, seasoned, and pan-fried until golden, then piled onto a soft bun with a tangy, creamy sauce and crisp toppings. It’s quick enough for a weeknight but satisfying enough for a game-day spread.

Ingredients

  • 1 pork tenderloin (about 1 lb / 450 g), trimmed
  • 1 cup (120 g) all-purpose flour
  • 1 tsp (5 g) garlic powder
  • 1 tsp (5 g) onion powder
  • 1 tsp (5 g) smoked paprika
  • 1 tsp (2 g) kosher salt, plus more to taste
  • 1/2 tsp (1 g) black pepper
  • 1/2 cup (120 ml) buttermilk
  • 1 large egg
  • 1 cup (120 g) panko breadcrumbs
  • 1/2 cup (120 ml) vegetable oil, for frying
  • 4 soft sandwich buns (like brioche or potato rolls)
  • For the sauce: 1/2 cup (120 g) mayonnaise
  • 2 tbsp (30 g) Dijon mustard
  • 1 tbsp (15 ml) pickle juice (from a jar of dill pickles)
  • 1 tsp (5 ml) hot sauce (like Frank’s RedHot)
  • For serving: sliced dill pickles, thinly sliced red onion, lettuce leaves

Instructions

  1. Slice the pork tenderloin crosswise into 8 equal medallions, about 1/2-inch (1.3 cm) thick. Place each medallion between two pieces of plastic wrap and pound with a meat mallet or rolling pin until about 1/4-inch (6 mm) thick.
  2. In a shallow dish, whisk together the flour, garlic powder, onion powder, smoked paprika, salt, and black pepper. In a second shallow dish, whisk the buttermilk and egg until combined. Place the panko in a third shallow dish.
  3. Dredge each pork slice in the flour mixture, shaking off excess. Dip into the buttermilk-egg mixture, letting excess drip off, then press into the panko to coat evenly. Place the breaded slices on a plate.
  4. Heat the vegetable oil in a large skillet over medium-high heat until shimmering (about 350°F / 175°C). Working in batches, fry the pork slices for 2–3 minutes per side, until golden brown and crispy. The pork is safe to eat when it reaches a USDA FSIS safe minimum internal temperature of 145°F (63°C), followed by a 3-minute rest. Transfer to a paper-towel-lined plate.
  5. In a small bowl, stir together the mayonnaise, Dijon mustard, pickle juice, and hot sauce. Set aside.
  6. Toast the buns lightly in a dry skillet or under a broiler. Spread the sauce on both cut sides of each bun.
  7. Place two pork slices on each bottom bun. Top with pickles, red onion, and lettuce. Close the sandwiches and serve immediately.

Tips

  • Don’t skip pounding the pork—it ensures even cooking and a tender bite. If you prefer extra-crispy coating, double-dip: flour, egg, flour, egg, then panko.
  • Use a thermometer to check doneness. Pork tenderloin is lean, so overcooking makes it dry; pull it at 145°F (63°C) and let it rest.
  • Substitute buttermilk with 1/2 cup (120 ml) regular milk mixed with 1 tsp (5 ml) lemon juice or vinegar, if needed. This will slightly change the tanginess.
  • For a gluten-free version, use gluten-free flour and panko. The coating will be a bit less crisp, but still delicious.

Serving Suggestions

Serve these sandwiches with a side of crispy fries, coleslaw, or a simple green salad. They also pair well with pickled vegetables or a cold beer (for adults of legal drinking age).

Variations

  • Spicy Kick: Add 1/2 tsp cayenne pepper to the flour mixture and increase hot sauce in the sauce to 2 tbsp (30 ml).
  • BBQ Style: Swap the mustard sauce for your favorite barbecue sauce and top with crispy fried onions.
  • Italian Twist: Replace the paprika with Italian seasoning and use marinara sauce instead of the mustard sauce; top with provolone cheese.
  • Air Fryer: Cook breaded pork at 400°F (200°C) for 8–10 minutes, flipping halfway, until internal temperature reaches 145°F (63°C).

Storage and Reheating

Store leftover cooked pork slices in an airtight container in the refrigerator for up to 3 days. Keep the sauce and buns separate. To reheat, place the pork on a baking sheet and warm in a 350°F (175°C) oven for 5–7 minutes, until hot and crisp. Alternatively, reheat in an air fryer at 375°F (190°C) for 3–4 minutes. Avoid microwaving, as it makes the coating soggy.

Frequently Asked Questions

Can I use pork loin instead of tenderloin? Yes, but pork loin is leaner and can dry out faster. Slice it thin and pound to the same thickness; adjust cooking time as needed.

What can I use instead of buttermilk? A mixture of 1/2 cup (120 ml) milk with 1 tsp (5 ml) lemon juice or white vinegar works well. Let it sit for 5 minutes before using.

How do I keep the breading from falling off? Make sure the pork is dry before dredging, and press the panko firmly onto the meat. Let the breaded slices rest for 5 minutes before frying.

Can I make this ahead of time? You can bread the pork slices up to a day in advance and refrigerate them uncovered on a rack. Fry just before serving.

What’s the best oil for frying? Use a neutral oil with a high smoke point, like vegetable, canola, or peanut oil. Avoid olive oil for deep frying.

Is this sandwich authentic to Cleveland? Yes, the pork tenderloin sandwich is a regional favorite in the Midwest, and Michael Symon’s version is a celebrated take. Many restaurants have their own variations.

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Safety notes: safe minimum internal temperatures from USDA FSIS; raw and undercooked fish guidance from the U.S. FDA. Food safety notes

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